| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEM22837.1 | SEM52619.1 | SAMN05444853_10923 | SAMN05444853_12213 | Betaine-homocysteine S-methyltransferase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.933 |
| SEM22837.1 | SEM59649.1 | SAMN05444853_10923 | SAMN05444853_12722 | Betaine-homocysteine S-methyltransferase. | GAF domain-containing protein. | 0.900 |
| SEM22837.1 | metK | SAMN05444853_10923 | SAMN05444853_10370 | Betaine-homocysteine S-methyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.924 |
| SEM35219.1 | SEM57112.1 | SAMN05444853_11353 | SAMN05444853_12510 | DNA (cytosine-5)-methyltransferase 1. | DNA (cytosine-5)-methyltransferase 1. | 0.930 |
| SEM35219.1 | metK | SAMN05444853_11353 | SAMN05444853_10370 | DNA (cytosine-5)-methyltransferase 1. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.908 |
| SEM52619.1 | SEM22837.1 | SAMN05444853_12213 | SAMN05444853_10923 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Betaine-homocysteine S-methyltransferase. | 0.933 |
| SEM52619.1 | SEM56904.1 | SAMN05444853_12213 | SAMN05444853_1253 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Biotin--[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase. | 0.491 |
| SEM52619.1 | glyA | SAMN05444853_12213 | SAMN05444853_1381 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.633 |
| SEM52619.1 | metK | SAMN05444853_12213 | SAMN05444853_10370 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.687 |
| SEM52619.1 | purF | SAMN05444853_12213 | SAMN05444853_1269 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; Belongs to the GARS family. | 0.408 |
| SEM52619.1 | rpoC | SAMN05444853_12213 | SAMN05444853_10239 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.538 |
| SEM56904.1 | SEM52619.1 | SAMN05444853_1253 | SAMN05444853_12213 | Biotin--[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.491 |
| SEM56904.1 | metK | SAMN05444853_1253 | SAMN05444853_10370 | Biotin--[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.685 |
| SEM57112.1 | SEM35219.1 | SAMN05444853_12510 | SAMN05444853_11353 | DNA (cytosine-5)-methyltransferase 1. | DNA (cytosine-5)-methyltransferase 1. | 0.930 |
| SEM57112.1 | metK | SAMN05444853_12510 | SAMN05444853_10370 | DNA (cytosine-5)-methyltransferase 1. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.908 |
| SEM59649.1 | SEM22837.1 | SAMN05444853_12722 | SAMN05444853_10923 | GAF domain-containing protein. | Betaine-homocysteine S-methyltransferase. | 0.900 |
| SEM59649.1 | metK | SAMN05444853_12722 | SAMN05444853_10370 | GAF domain-containing protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| glyA | SEM52619.1 | SAMN05444853_1381 | SAMN05444853_12213 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.633 |
| glyA | groL | SAMN05444853_1381 | SAMN05444853_104125 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.604 |
| glyA | metK | SAMN05444853_1381 | SAMN05444853_10370 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.742 |
