| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEM22837.1 | SEM52619.1 | SAMN05444853_10923 | SAMN05444853_12213 | Betaine-homocysteine S-methyltransferase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.909 |
| SEM22837.1 | SEM59649.1 | SAMN05444853_10923 | SAMN05444853_12722 | Betaine-homocysteine S-methyltransferase. | GAF domain-containing protein. | 0.900 |
| SEM22837.1 | guaA | SAMN05444853_10923 | SAMN05444853_101127 | Betaine-homocysteine S-methyltransferase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.438 |
| SEM22837.1 | metK | SAMN05444853_10923 | SAMN05444853_10370 | Betaine-homocysteine S-methyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.931 |
| SEM35219.1 | SEM57112.1 | SAMN05444853_11353 | SAMN05444853_12510 | DNA (cytosine-5)-methyltransferase 1. | DNA (cytosine-5)-methyltransferase 1. | 0.930 |
| SEM35219.1 | metK | SAMN05444853_11353 | SAMN05444853_10370 | DNA (cytosine-5)-methyltransferase 1. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.908 |
| SEM52619.1 | SEM22837.1 | SAMN05444853_12213 | SAMN05444853_10923 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Betaine-homocysteine S-methyltransferase. | 0.909 |
| SEM52619.1 | glyA | SAMN05444853_12213 | SAMN05444853_1381 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.501 |
| SEM52619.1 | guaA | SAMN05444853_12213 | SAMN05444853_101127 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.443 |
| SEM52619.1 | metK | SAMN05444853_12213 | SAMN05444853_10370 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.622 |
| SEM57112.1 | SEM35219.1 | SAMN05444853_12510 | SAMN05444853_11353 | DNA (cytosine-5)-methyltransferase 1. | DNA (cytosine-5)-methyltransferase 1. | 0.930 |
| SEM57112.1 | metK | SAMN05444853_12510 | SAMN05444853_10370 | DNA (cytosine-5)-methyltransferase 1. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.908 |
| SEM59649.1 | SEM22837.1 | SAMN05444853_12722 | SAMN05444853_10923 | GAF domain-containing protein. | Betaine-homocysteine S-methyltransferase. | 0.900 |
| SEM59649.1 | metK | SAMN05444853_12722 | SAMN05444853_10370 | GAF domain-containing protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| coaD | guaA | SAMN05444853_11233 | SAMN05444853_101127 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.608 |
| coaD | metK | SAMN05444853_11233 | SAMN05444853_10370 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.599 |
| glyA | SEM52619.1 | SAMN05444853_1381 | SAMN05444853_12213 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.501 |
| glyA | guaA | SAMN05444853_1381 | SAMN05444853_101127 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.538 |
| glyA | metK | SAMN05444853_1381 | SAMN05444853_10370 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.682 |
| glyA | purF | SAMN05444853_1381 | SAMN05444853_1269 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; Belongs to the GARS family. | 0.766 |