STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEM19860.13D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing); Belongs to the TPP enzyme family. (646 aa)    
Predicted Functional Partners:
iolE
Inosose dehydratase; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family.
 
 
 0.997
SEM19907.1
5-deoxy-glucuronate isomerase.
 
 
 0.997
SEM19887.1
5-dehydro-2-deoxygluconokinase.
 
  
 0.972
SEM19810.1
Myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase.
 
  
 0.961
SEM19782.1
Predicted dehydrogenase.
 
  
 0.918
SEM19936.1
Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase.
  
 0.592
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
  
 0.565
SEM19963.1
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains.
 
   
 0.499
SEM01653.1
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
  
  
 0.431
SEM11831.1
Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.
  
  
 0.408
Your Current Organism:
Pasteurella skyensis
NCBI taxonomy Id: 97481
Other names: DSM 24204, NCIMB 13593, NCTC 13204, P. skyensis, Pasteurella skyensis Birkbeck et al. 2002, strain 95A1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.