Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SEM19556.1Peptidyl-prolyl cis-trans isomerase D. (623 aa)    
Predicted Functional Partners:
SEM35426.1
2-oxoglutarate dehydrogenase E1 component.
  
 0.877
SEM14769.1
Glutathione reductase (NADPH).
  
 0.829
SEM39695.1
Dihydrolipoamide dehydrogenase.
  
 0.829
SEM20151.1
Two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB.
 
 
 0.780
SEM01725.1
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
  
 
 0.746
SEL90219.1
Peptidyl-prolyl cis-trans isomerase SurA.
 
  
 0.743
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.742
bamA
Outer membrane protein insertion porin family; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
 
 0.725
SEM62300.1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.725
SEM39647.1
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.701
Your Current Organism:
Pasteurella skyensis
NCBI taxonomy Id: 97481
Other names: DSM 24204, NCIMB 13593, NCTC 13204, P. skyensis, Pasteurella skyensis Birkbeck et al. 2002, strain 95A1
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