| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEM02230.1 | SEM15031.1 | SAMN05444853_10379 | SAMN05444853_10674 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine beta-lyase. | 0.990 |
| SEM02230.1 | SEM22837.1 | SAMN05444853_10379 | SAMN05444853_10923 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Betaine-homocysteine S-methyltransferase. | 0.823 |
| SEM02230.1 | SEM52619.1 | SAMN05444853_10379 | SAMN05444853_12213 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.538 |
| SEM02230.1 | metK | SAMN05444853_10379 | SAMN05444853_10370 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.437 |
| SEM02230.1 | msrA | SAMN05444853_10379 | SAMN05444853_10163 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Peptide methionine sulfoxide reductase msrA/msrB; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.564 |
| SEM14567.1 | SEM22837.1 | SAMN05444853_10656 | SAMN05444853_10923 | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | Betaine-homocysteine S-methyltransferase. | 0.919 |
| SEM15031.1 | SEM02230.1 | SAMN05444853_10674 | SAMN05444853_10379 | Cystathionine beta-lyase. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.990 |
| SEM15031.1 | SEM22837.1 | SAMN05444853_10674 | SAMN05444853_10923 | Cystathionine beta-lyase. | Betaine-homocysteine S-methyltransferase. | 0.943 |
| SEM15031.1 | SEM52619.1 | SAMN05444853_10674 | SAMN05444853_12213 | Cystathionine beta-lyase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.959 |
| SEM15031.1 | ilvA | SAMN05444853_10674 | SAMN05444853_1368 | Cystathionine beta-lyase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.879 |
| SEM15031.1 | metK | SAMN05444853_10674 | SAMN05444853_10370 | Cystathionine beta-lyase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.444 |
| SEM15031.1 | msrA | SAMN05444853_10674 | SAMN05444853_10163 | Cystathionine beta-lyase. | Peptide methionine sulfoxide reductase msrA/msrB; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.431 |
| SEM15031.1 | thrB | SAMN05444853_10674 | SAMN05444853_12212 | Cystathionine beta-lyase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.858 |
| SEM22810.1 | SEM22837.1 | SAMN05444853_10922 | SAMN05444853_10923 | DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. | Betaine-homocysteine S-methyltransferase. | 0.613 |
| SEM22837.1 | SEM02230.1 | SAMN05444853_10923 | SAMN05444853_10379 | Betaine-homocysteine S-methyltransferase. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.823 |
| SEM22837.1 | SEM14567.1 | SAMN05444853_10923 | SAMN05444853_10656 | Betaine-homocysteine S-methyltransferase. | Betaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. | 0.919 |
| SEM22837.1 | SEM15031.1 | SAMN05444853_10923 | SAMN05444853_10674 | Betaine-homocysteine S-methyltransferase. | Cystathionine beta-lyase. | 0.943 |
| SEM22837.1 | SEM22810.1 | SAMN05444853_10923 | SAMN05444853_10922 | Betaine-homocysteine S-methyltransferase. | DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. | 0.613 |
| SEM22837.1 | SEM52619.1 | SAMN05444853_10923 | SAMN05444853_12213 | Betaine-homocysteine S-methyltransferase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.933 |
| SEM22837.1 | SEM59649.1 | SAMN05444853_10923 | SAMN05444853_12722 | Betaine-homocysteine S-methyltransferase. | GAF domain-containing protein. | 0.900 |
