| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEM20151.1 | SEM23755.1 | SAMN05444853_10824 | SAMN05444853_10959 | Two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB. | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | 0.640 |
| SEM20151.1 | ftsZ | SAMN05444853_10824 | SAMN05444853_10785 | Two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.515 |
| SEM20151.1 | slmA | SAMN05444853_10824 | SAMN05444853_10957 | Two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB. | TetR/AcrR family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.530 |
| SEM23662.1 | SEM23734.1 | SAMN05444853_10955 | SAMN05444853_10958 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Hypothetical protein; Belongs to the UPF0270 family. | 0.822 |
| SEM23662.1 | SEM23755.1 | SAMN05444853_10955 | SAMN05444853_10959 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | 0.603 |
| SEM23662.1 | dut | SAMN05444853_10955 | SAMN05444853_10956 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.980 |
| SEM23662.1 | slmA | SAMN05444853_10955 | SAMN05444853_10957 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TetR/AcrR family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.832 |
| SEM23734.1 | SEM23662.1 | SAMN05444853_10958 | SAMN05444853_10955 | Hypothetical protein; Belongs to the UPF0270 family. | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.822 |
| SEM23734.1 | SEM23755.1 | SAMN05444853_10958 | SAMN05444853_10959 | Hypothetical protein; Belongs to the UPF0270 family. | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | 0.614 |
| SEM23734.1 | SEM35040.1 | SAMN05444853_10958 | SAMN05444853_11346 | Hypothetical protein; Belongs to the UPF0270 family. | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated; Belongs to the SeqA family. | 0.565 |
| SEM23734.1 | dut | SAMN05444853_10958 | SAMN05444853_10956 | Hypothetical protein; Belongs to the UPF0270 family. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.823 |
| SEM23734.1 | slmA | SAMN05444853_10958 | SAMN05444853_10957 | Hypothetical protein; Belongs to the UPF0270 family. | TetR/AcrR family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.897 |
| SEM23755.1 | SEM20151.1 | SAMN05444853_10959 | SAMN05444853_10824 | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | Two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB. | 0.640 |
| SEM23755.1 | SEM23662.1 | SAMN05444853_10959 | SAMN05444853_10955 | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.603 |
| SEM23755.1 | SEM23734.1 | SAMN05444853_10959 | SAMN05444853_10958 | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | Hypothetical protein; Belongs to the UPF0270 family. | 0.614 |
| SEM23755.1 | dut | SAMN05444853_10959 | SAMN05444853_10956 | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.602 |
| SEM23755.1 | slmA | SAMN05444853_10959 | SAMN05444853_10957 | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | TetR/AcrR family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.616 |
| SEM35040.1 | SEM23734.1 | SAMN05444853_11346 | SAMN05444853_10958 | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated; Belongs to the SeqA family. | Hypothetical protein; Belongs to the UPF0270 family. | 0.565 |
| SEM35040.1 | dnaX | SAMN05444853_11346 | SAMN05444853_101145 | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated; Belongs to the SeqA family. | DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.426 |
| SEM35040.1 | mfd | SAMN05444853_11346 | SAMN05444853_11123 | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated; Belongs to the SeqA family. | Transcription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.501 |
