| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEM02333.1 | SEM11355.1 | SAMN05444853_10383 | SAMN05444853_10569 | Hypothetical protein; Belongs to the UPF0149 family. | sigma-E factor negative regulatory protein RseA. | 0.658 |
| SEM02333.1 | SEM23734.1 | SAMN05444853_10383 | SAMN05444853_10958 | Hypothetical protein; Belongs to the UPF0149 family. | Hypothetical protein; Belongs to the UPF0270 family. | 0.511 |
| SEM02333.1 | SEM35040.1 | SAMN05444853_10383 | SAMN05444853_11346 | Hypothetical protein; Belongs to the UPF0149 family. | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated; Belongs to the SeqA family. | 0.673 |
| SEM02333.1 | SEM42799.1 | SAMN05444853_10383 | SAMN05444853_11729 | Hypothetical protein; Belongs to the UPF0149 family. | Hypothetical protein. | 0.681 |
| SEM02333.1 | yihI | SAMN05444853_10383 | SAMN05444853_10832 | Hypothetical protein; Belongs to the UPF0149 family. | Hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.713 |
| SEM11355.1 | SEM02333.1 | SAMN05444853_10569 | SAMN05444853_10383 | sigma-E factor negative regulatory protein RseA. | Hypothetical protein; Belongs to the UPF0149 family. | 0.658 |
| SEM11355.1 | SEM23734.1 | SAMN05444853_10569 | SAMN05444853_10958 | sigma-E factor negative regulatory protein RseA. | Hypothetical protein; Belongs to the UPF0270 family. | 0.649 |
| SEM11355.1 | SEM35040.1 | SAMN05444853_10569 | SAMN05444853_11346 | sigma-E factor negative regulatory protein RseA. | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated; Belongs to the SeqA family. | 0.772 |
| SEM11355.1 | SEM42799.1 | SAMN05444853_10569 | SAMN05444853_11729 | sigma-E factor negative regulatory protein RseA. | Hypothetical protein. | 0.770 |
| SEM11355.1 | yihI | SAMN05444853_10569 | SAMN05444853_10832 | sigma-E factor negative regulatory protein RseA. | Hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.773 |
| SEM23618.1 | SEM23662.1 | SAMN05444853_10953 | SAMN05444853_10955 | MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein. | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.479 |
| SEM23618.1 | SEM23734.1 | SAMN05444853_10953 | SAMN05444853_10958 | MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein. | Hypothetical protein; Belongs to the UPF0270 family. | 0.470 |
| SEM23618.1 | dut | SAMN05444853_10953 | SAMN05444853_10956 | MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.483 |
| SEM23618.1 | slmA | SAMN05444853_10953 | SAMN05444853_10957 | MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein. | TetR/AcrR family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.470 |
| SEM23662.1 | SEM23618.1 | SAMN05444853_10955 | SAMN05444853_10953 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein. | 0.479 |
| SEM23662.1 | SEM23734.1 | SAMN05444853_10955 | SAMN05444853_10958 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Hypothetical protein; Belongs to the UPF0270 family. | 0.822 |
| SEM23662.1 | SEM23755.1 | SAMN05444853_10955 | SAMN05444853_10959 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | CRP/FNR family transcriptional regulator, cyclic AMP receptor protein. | 0.603 |
| SEM23662.1 | dut | SAMN05444853_10955 | SAMN05444853_10956 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.980 |
| SEM23662.1 | slmA | SAMN05444853_10955 | SAMN05444853_10957 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TetR/AcrR family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.832 |
| SEM23734.1 | SEM02333.1 | SAMN05444853_10958 | SAMN05444853_10383 | Hypothetical protein; Belongs to the UPF0270 family. | Hypothetical protein; Belongs to the UPF0149 family. | 0.511 |
