SEM26404.1 protein (Pasteurella skyensis) - STRING interaction network

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Score

SEM26404.1

L-threonine aldolase. (332 aa)

Predicted Functional Partners:

glyA

0.936

ilvA

0.926

SEL98511.1

0.924

SEM29501.1

0.905

ychF

0.750

glnS

0.477

Your Current Organism:

Pasteurella skyensis

NCBI taxonomy Id: 97481
Other names: DSM 24204, NCIMB 13593, NCTC 13204, P. skyensis, Pasteurella skyensis Birkbeck et al. 2002, strain 95A1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEL98511.1	SEM26404.1	SAMN05444853_102150	SAMN05444853_11049	Threonine synthase.	L-threonine aldolase.	0.924
SEL98511.1	ilvA	SAMN05444853_102150	SAMN05444853_1368	Threonine synthase.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.947
SEM26404.1	SEL98511.1	SAMN05444853_11049	SAMN05444853_102150	L-threonine aldolase.	Threonine synthase.	0.924
SEM26404.1	SEM29501.1	SAMN05444853_11049	SAMN05444853_11162	L-threonine aldolase.	Hypothetical protein/3-hydroxy acid dehydrogenase / malonic semialdehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.905
SEM26404.1	glnS	SAMN05444853_11049	SAMN05444853_11048	L-threonine aldolase.	glutaminyl-tRNA synthetase.	0.477
SEM26404.1	glyA	SAMN05444853_11049	SAMN05444853_1381	L-threonine aldolase.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.936
SEM26404.1	ilvA	SAMN05444853_11049	SAMN05444853_1368	L-threonine aldolase.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.926
SEM26404.1	ychF	SAMN05444853_11049	SAMN05444853_10241	L-threonine aldolase.	Hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.	0.750
SEM29501.1	SEM26404.1	SAMN05444853_11162	SAMN05444853_11049	Hypothetical protein/3-hydroxy acid dehydrogenase / malonic semialdehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	L-threonine aldolase.	0.905
glnS	SEM26404.1	SAMN05444853_11048	SAMN05444853_11049	glutaminyl-tRNA synthetase.	L-threonine aldolase.	0.477
glyA	SEM26404.1	SAMN05444853_1381	SAMN05444853_11049	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-threonine aldolase.	0.936
glyA	ilvA	SAMN05444853_1381	SAMN05444853_1368	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.925
ilvA	SEL98511.1	SAMN05444853_1368	SAMN05444853_102150	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Threonine synthase.	0.947
ilvA	SEM26404.1	SAMN05444853_1368	SAMN05444853_11049	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	L-threonine aldolase.	0.926
ilvA	glyA	SAMN05444853_1368	SAMN05444853_1381	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.925
ychF	SEM26404.1	SAMN05444853_10241	SAMN05444853_11049	Hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.	L-threonine aldolase.	0.750