| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEM02602.1 | SEM44565.1 | SAMN05444853_10396 | SAMN05444853_11831 | Formate C-acetyltransferase. | Alanine-synthesizing transaminase. | 0.815 |
| SEM02602.1 | SEM62803.1 | SAMN05444853_10396 | SAMN05444853_1321 | Formate C-acetyltransferase. | Branched-chain amino acid aminotransferase. | 0.800 |
| SEM02602.1 | SEM65043.1 | SAMN05444853_10396 | SAMN05444853_1366 | Formate C-acetyltransferase. | Acetolactate synthase, small subunit. | 0.900 |
| SEM02602.1 | ilvA | SAMN05444853_10396 | SAMN05444853_1368 | Formate C-acetyltransferase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.813 |
| SEM02602.1 | leuA | SAMN05444853_10396 | SAMN05444853_1206 | Formate C-acetyltransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.902 |
| SEM44565.1 | SEM02602.1 | SAMN05444853_11831 | SAMN05444853_10396 | Alanine-synthesizing transaminase. | Formate C-acetyltransferase. | 0.815 |
| SEM44565.1 | SEM52619.1 | SAMN05444853_11831 | SAMN05444853_12213 | Alanine-synthesizing transaminase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.728 |
| SEM44565.1 | SEM62803.1 | SAMN05444853_11831 | SAMN05444853_1321 | Alanine-synthesizing transaminase. | Branched-chain amino acid aminotransferase. | 0.923 |
| SEM44565.1 | ilvD | SAMN05444853_11831 | SAMN05444853_1365 | Alanine-synthesizing transaminase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.916 |
| SEM44565.1 | leuA | SAMN05444853_11831 | SAMN05444853_1206 | Alanine-synthesizing transaminase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.912 |
| SEM52619.1 | SEM44565.1 | SAMN05444853_12213 | SAMN05444853_11831 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Alanine-synthesizing transaminase. | 0.728 |
| SEM52619.1 | SEM62803.1 | SAMN05444853_12213 | SAMN05444853_1321 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Branched-chain amino acid aminotransferase. | 0.928 |
| SEM52619.1 | ilvA | SAMN05444853_12213 | SAMN05444853_1368 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.750 |
| SEM52619.1 | ilvC | SAMN05444853_12213 | SAMN05444853_1369 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.721 |
| SEM52619.1 | ilvD | SAMN05444853_12213 | SAMN05444853_1365 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.766 |
| SEM52619.1 | leuA | SAMN05444853_12213 | SAMN05444853_1206 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.808 |
| SEM52619.1 | leuB | SAMN05444853_12213 | SAMN05444853_1205 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.736 |
| SEM52619.1 | thrB | SAMN05444853_12213 | SAMN05444853_12212 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
| SEM62803.1 | SEM02602.1 | SAMN05444853_1321 | SAMN05444853_10396 | Branched-chain amino acid aminotransferase. | Formate C-acetyltransferase. | 0.800 |
| SEM62803.1 | SEM44565.1 | SAMN05444853_1321 | SAMN05444853_11831 | Branched-chain amino acid aminotransferase. | Alanine-synthesizing transaminase. | 0.923 |
