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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNRF3E3 ubiquitin-protein ligase ZNRF3. (844 aa)    
Predicted Functional Partners:
RSPO4
R-spondin-4.
   
 0.962
RSPO1
R-spondin-1.
   
 0.958
RSPO3
R-spondin-3.
   
 0.948
FZD4
Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.945
FZD6
Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.937
FZD5
Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.929
FZD8
Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.929
FZD9
Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.917
FZD10
Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.917
FZD3
Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.912
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.