Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
F2RL1Proteinase-activated receptor 2. (315 aa)    
Predicted Functional Partners:
GNAQ
Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1.
    
 0.926
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
    
 0.895
LOC111171097
Cathepsin G-like isoform X1; Belongs to the peptidase S1 family.
   
 0.718
LOC111163114
Granzyme A; Belongs to the peptidase S1 family.
   
 0.711
GZMA
Granzyme A; Belongs to the peptidase S1 family.
   
 0.711
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
    
 0.710
S1PR2
Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.
     
 0.550
ARHGEF1
Rho guanine nucleotide exchange factor 1 isoform X1.
      
 0.484
CRLF2
Cytokine receptor-like factor 2.
      
 0.459
LOC111169288
Transmembrane emp24 domain-containing protein 2-like.
    
 0.418
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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