MAP3K21 protein (Delphinapterus leucas) - STRING interaction network

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Score

MAP3K21

Mitogen-activated protein kinase kinase kinase. (1054 aa)

Predicted Functional Partners:

CNNM2

0.606

TAB1

0.591

TRAF6

0.586

MIB2

0.569

CD247

0.566

SGO1

0.561

TRADD

0.560

FADD

0.549

MAP2K4

0.533

TAB2

0.512

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	FADD	A0A2Y9MEJ4	A0A2Y9PNL8	T-cell surface glycoprotein CD3 zeta chain isoform X1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.454
CD247	MAP3K21	A0A2Y9MEJ4	A0A2Y9LGL8	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Mitogen-activated protein kinase kinase kinase.	0.566
CNNM2	MAP3K21	A0A2Y9MRJ3	A0A2Y9LGL8	Metal transporter CNNM2 isoform X1.	Mitogen-activated protein kinase kinase kinase.	0.606
FADD	CD247	A0A2Y9PNL8	A0A2Y9MEJ4	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	T-cell surface glycoprotein CD3 zeta chain isoform X1.	0.454
FADD	MAP2K4	A0A2Y9PNL8	A0A2Y9PYR4	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	0.418
FADD	MAP3K21	A0A2Y9PNL8	A0A2Y9LGL8	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Mitogen-activated protein kinase kinase kinase.	0.549
FADD	MIB2	A0A2Y9PNL8	A0A2Y9QG65	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	E3 ubiquitin-protein ligase MIB2 isoform X1.	0.569
FADD	TAB1	A0A2Y9PNL8	A0A2Y9Q156	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1.	0.575
FADD	TAB2	A0A2Y9PNL8	A0A2Y9LY00	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1.	0.582
FADD	TRADD	A0A2Y9PNL8	A0A2Y9P782	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	0.999
FADD	TRAF6	A0A2Y9PNL8	A0A2Y9PAB2	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.701
MAP2K4	FADD	A0A2Y9PYR4	A0A2Y9PNL8	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.418
MAP2K4	MAP3K21	A0A2Y9PYR4	A0A2Y9LGL8	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase.	0.533
MAP2K4	TAB1	A0A2Y9PYR4	A0A2Y9Q156	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1.	0.949
MAP2K4	TAB2	A0A2Y9PYR4	A0A2Y9LY00	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1.	0.944
MAP2K4	TRAF6	A0A2Y9PYR4	A0A2Y9PAB2	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.640
MAP3K21	CD247	A0A2Y9LGL8	A0A2Y9MEJ4	Mitogen-activated protein kinase kinase kinase.	T-cell surface glycoprotein CD3 zeta chain isoform X1.	0.566
MAP3K21	CNNM2	A0A2Y9LGL8	A0A2Y9MRJ3	Mitogen-activated protein kinase kinase kinase.	Metal transporter CNNM2 isoform X1.	0.606
MAP3K21	FADD	A0A2Y9LGL8	A0A2Y9PNL8	Mitogen-activated protein kinase kinase kinase.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.549
MAP3K21	MAP2K4	A0A2Y9LGL8	A0A2Y9PYR4	Mitogen-activated protein kinase kinase kinase.	Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily.	0.533