Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)    
Predicted Functional Partners:
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
   
0.995
SEL1L
Protein sel-1 homolog 1 isoform X1.
   
 0.971
OS9
Protein OS-9 isoform X1.
   
 0.947
VCP
Transitional endoplasmic reticulum ATPase isoform X1; Belongs to the AAA ATPase family.
   
 0.938
SYVN1
E3 ubiquitin-protein ligase synoviolin.
   
 0.936
DERL2
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
  
  
 
0.913
AMFR
E3 ubiquitin-protein ligase AMFR.
   
 0.906
FAF2
FAS-associated factor 2 isoform X1.
   
 
 0.891
ERLEC1
Endoplasmic reticulum lectin 1 isoform X1.
   
 0.864
SELENOS
Selenoprotein S isoform X1.
   
 0.855
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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