node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMDHD1 | EPHX2 | A0A2Y9M7H1 | A0A2Y9Q567 | Probable imidazolonepropionase isoform X2. | Bifunctional epoxide hydrolase 2 isoform X1. | 0.402 |
AMDHD1 | MTAP | A0A2Y9M7H1 | A0A2Y9LJL6 | Probable imidazolonepropionase isoform X2. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.711 |
AMDHD1 | NT5E | A0A2Y9M7H1 | A0A2Y9LDY5 | Probable imidazolonepropionase isoform X2. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.828 |
APRT | GDA | A0A2Y9P040 | A0A2Y9N4Q6 | Adenine phosphoribosyltransferase. | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | 0.965 |
APRT | MRI1 | A0A2Y9P040 | A0A2Y9LZD5 | Adenine phosphoribosyltransferase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.484 |
APRT | MTAP | A0A2Y9P040 | A0A2Y9LJL6 | Adenine phosphoribosyltransferase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.980 |
APRT | NT5E | A0A2Y9P040 | A0A2Y9LDY5 | Adenine phosphoribosyltransferase. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.944 |
EPHX2 | AMDHD1 | A0A2Y9Q567 | A0A2Y9M7H1 | Bifunctional epoxide hydrolase 2 isoform X1. | Probable imidazolonepropionase isoform X2. | 0.402 |
EPHX2 | GDA | A0A2Y9Q567 | A0A2Y9N4Q6 | Bifunctional epoxide hydrolase 2 isoform X1. | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | 0.402 |
EPHX2 | MTAP | A0A2Y9Q567 | A0A2Y9LJL6 | Bifunctional epoxide hydrolase 2 isoform X1. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.883 |
EPHX2 | NT5E | A0A2Y9Q567 | A0A2Y9LDY5 | Bifunctional epoxide hydrolase 2 isoform X1. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.800 |
EPHX2 | OGG1 | A0A2Y9Q567 | A0A2Y9MTA9 | Bifunctional epoxide hydrolase 2 isoform X1. | N-glycosylase/DNA lyase isoform X1. | 0.479 |
GDA | APRT | A0A2Y9N4Q6 | A0A2Y9P040 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | Adenine phosphoribosyltransferase. | 0.965 |
GDA | EPHX2 | A0A2Y9N4Q6 | A0A2Y9Q567 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | Bifunctional epoxide hydrolase 2 isoform X1. | 0.402 |
GDA | MTAP | A0A2Y9N4Q6 | A0A2Y9LJL6 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.711 |
GDA | NT5E | A0A2Y9N4Q6 | A0A2Y9LDY5 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.843 |
HDDC2 | MTAP | A0A2Y9M2K2 | A0A2Y9LJL6 | HD domain-containing protein 2. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.824 |
MRI1 | APRT | A0A2Y9LZD5 | A0A2Y9P040 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Adenine phosphoribosyltransferase. | 0.484 |
MRI1 | MTAP | A0A2Y9LZD5 | A0A2Y9LJL6 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.990 |
MRI1 | SMS | A0A2Y9LZD5 | A0A2Y9M392 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Spermine synthase. | 0.426 |