| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | CD40 | Q9XS78 | A0A2Y9MFP5 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Tumor necrosis factor receptor superfamily member 5 isoform X1. | 0.910 |
| CD4 | CD40LG | Q9XS78 | A0A2Y9LKH7 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | 0.887 |
| CD4 | CD80 | Q9XS78 | A0A2Y9MFX2 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | T-lymphocyte activation antigen CD80 isoform X1. | 0.927 |
| CD4 | CD86 | Q9XS78 | A0A2Y9MK30 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | T-lymphocyte activation antigen CD86 isoform X1. | 0.923 |
| CD4 | CTLA4 | Q9XS78 | A0A2Y9MVX1 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Cytotoxic T-lymphocyte protein 4 isoform X1. | 0.890 |
| CD4 | CXCR5 | Q9XS78 | A0A2Y9M4C4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. | 0.877 |
| CD4 | ICOS | Q9XS78 | A0A2Y9MMG7 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Inducible T-cell costimulator isoform X1. | 0.877 |
| CD4 | IL2 | Q9XS78 | Q9XT84 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.994 |
| CD4 | IL4 | Q9XS78 | A0A2Y9PNT9 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.993 |
| CD4 | LTBR | Q9XS78 | A0A2Y9NDQ3 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Tumor necrosis factor receptor superfamily member 3. | 0.514 |
| CD40 | CD4 | A0A2Y9MFP5 | Q9XS78 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.910 |
| CD40 | CD40LG | A0A2Y9MFP5 | A0A2Y9LKH7 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | 0.999 |
| CD40 | CD80 | A0A2Y9MFP5 | A0A2Y9MFX2 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | T-lymphocyte activation antigen CD80 isoform X1. | 0.886 |
| CD40 | CD86 | A0A2Y9MFP5 | A0A2Y9MK30 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | T-lymphocyte activation antigen CD86 isoform X1. | 0.902 |
| CD40 | CTLA4 | A0A2Y9MFP5 | A0A2Y9MVX1 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | Cytotoxic T-lymphocyte protein 4 isoform X1. | 0.776 |
| CD40 | CXCR5 | A0A2Y9MFP5 | A0A2Y9M4C4 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. | 0.782 |
| CD40 | ICOS | A0A2Y9MFP5 | A0A2Y9MMG7 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | Inducible T-cell costimulator isoform X1. | 0.778 |
| CD40 | IL2 | A0A2Y9MFP5 | Q9XT84 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.616 |
| CD40 | IL4 | A0A2Y9MFP5 | A0A2Y9PNT9 | Tumor necrosis factor receptor superfamily member 5 isoform X1. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.752 |
| CD40LG | CD4 | A0A2Y9LKH7 | Q9XS78 | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.887 |
STRING v12.5 is now available!
