PRMT5 protein (Delphinapterus leucas) - STRING interaction network

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PRMT5

Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)

Predicted Functional Partners:

LOC111180037

0.992

CLNS1A

0.951

LOC111178406

0.900

RIOK1

0.841

WDR33

0.822

COPRS

0.750

PRMT7

0.737

LOC111168531

0.712

LOC111168536

0.712

TEP1

0.710

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLNS1A	LOC111178406	A0A2Y9Q2M9	A0A2Y9P3M2	Methylosome subunit pICln isoform X1.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.951
CLNS1A	LOC111180037	A0A2Y9Q2M9	A0A2Y9P3H6	Methylosome subunit pICln isoform X1.	Methylosome protein 50-like.	0.980
CLNS1A	PRMT5	A0A2Y9Q2M9	A0A2Y9LKP8	Methylosome subunit pICln isoform X1.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.951
CLNS1A	PRMT7	A0A2Y9Q2M9	A0A2Y9NVN9	Methylosome subunit pICln isoform X1.	Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...]	0.495
CLNS1A	RIOK1	A0A2Y9Q2M9	A0A2Y9PI39	Methylosome subunit pICln isoform X1.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.564
CLNS1A	TEP1	A0A2Y9Q2M9	A0A2Y9P8B6	Methylosome subunit pICln isoform X1.	Telomerase protein component 1 isoform X1.	0.654
CLNS1A	WDR33	A0A2Y9Q2M9	A0A2Y9PH46	Methylosome subunit pICln isoform X1.	pre-mRNA 3' end processing protein WDR33 isoform X1.	0.809
COPRS	LOC111178406	A0A2Y9Q1L8	A0A2Y9P3M2	Coordinator of PRMT5 and differentiation stimulator.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.750
COPRS	LOC111180037	A0A2Y9Q1L8	A0A2Y9P3H6	Coordinator of PRMT5 and differentiation stimulator.	Methylosome protein 50-like.	0.763
COPRS	PRMT5	A0A2Y9Q1L8	A0A2Y9LKP8	Coordinator of PRMT5 and differentiation stimulator.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.750
COPRS	RIOK1	A0A2Y9Q1L8	A0A2Y9PI39	Coordinator of PRMT5 and differentiation stimulator.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.684
COPRS	WDR33	A0A2Y9Q1L8	A0A2Y9PH46	Coordinator of PRMT5 and differentiation stimulator.	pre-mRNA 3' end processing protein WDR33 isoform X1.	0.437
LOC111168531	LOC111178406	A0A2Y9MG41	A0A2Y9P3M2	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.712
LOC111168531	LOC111180037	A0A2Y9MG41	A0A2Y9P3H6	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Methylosome protein 50-like.	0.607
LOC111168531	PRMT5	A0A2Y9MG41	A0A2Y9LKP8	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.712
LOC111168531	PRMT7	A0A2Y9MG41	A0A2Y9NVN9	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...]	0.517
LOC111168531	TEP1	A0A2Y9MG41	A0A2Y9P8B6	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Telomerase protein component 1 isoform X1.	0.420
LOC111168531	WDR33	A0A2Y9MG41	A0A2Y9PH46	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	pre-mRNA 3' end processing protein WDR33 isoform X1.	0.516
LOC111168536	LOC111178406	A0A2Y9MLG6	A0A2Y9P3M2	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.712
LOC111168536	LOC111180037	A0A2Y9MLG6	A0A2Y9P3H6	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Methylosome protein 50-like.	0.607

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