KDM1A protein (Delphinapterus leucas) - STRING interaction network

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KDM1A

Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)

Predicted Functional Partners:

RCOR1

0.999

PHF21A

0.976

ZNF516

0.954

HMG20B

0.953

PRDM16

0.916

HDAC1

0.897

KDM4A

0.877

RCOR2

0.877

RCOR3

0.877

MTA3

0.872

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HDAC1	HMG20B	A0A2Y9N7S9	A0A2Y9LUG4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	annotation not available	0.781
HDAC1	KDM1A	A0A2Y9N7S9	A0A2Y9LLF1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.897
HDAC1	MTA3	A0A2Y9N7S9	A0A2Y9NDY3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Metastasis-associated protein MTA3 isoform X1.	0.840
HDAC1	PHF21A	A0A2Y9N7S9	A0A2Y9PQA0	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	PHD finger protein 21A isoform X1.	0.704
HDAC1	RCOR1	A0A2Y9N7S9	A0A2Y9NQW9	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	REST corepressor 1 isoform X1.	0.963
HDAC1	RCOR2	A0A2Y9N7S9	A0A2Y9PQ83	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	REST corepressor 2.	0.549
HDAC1	RCOR3	A0A2Y9N7S9	A0A2Y9Q0V4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	REST corepressor 3 isoform X1.	0.693
HMG20B	HDAC1	A0A2Y9LUG4	A0A2Y9N7S9	annotation not available	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.781
HMG20B	KDM1A	A0A2Y9LUG4	A0A2Y9LLF1	annotation not available	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.953
HMG20B	MTA3	A0A2Y9LUG4	A0A2Y9NDY3	annotation not available	Metastasis-associated protein MTA3 isoform X1.	0.402
HMG20B	PHF21A	A0A2Y9LUG4	A0A2Y9PQA0	annotation not available	PHD finger protein 21A isoform X1.	0.965
HMG20B	RCOR1	A0A2Y9LUG4	A0A2Y9NQW9	annotation not available	REST corepressor 1 isoform X1.	0.946
HMG20B	RCOR2	A0A2Y9LUG4	A0A2Y9PQ83	annotation not available	REST corepressor 2.	0.744
HMG20B	RCOR3	A0A2Y9LUG4	A0A2Y9Q0V4	annotation not available	REST corepressor 3 isoform X1.	0.744
KDM1A	HDAC1	A0A2Y9LLF1	A0A2Y9N7S9	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.897
KDM1A	HMG20B	A0A2Y9LLF1	A0A2Y9LUG4	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	annotation not available	0.953
KDM1A	KDM4A	A0A2Y9LLF1	A0A2Y9NAE7	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Lysine-specific demethylase 4A isoform X1.	0.877
KDM1A	MTA3	A0A2Y9LLF1	A0A2Y9NDY3	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Metastasis-associated protein MTA3 isoform X1.	0.872
KDM1A	PHF21A	A0A2Y9LLF1	A0A2Y9PQA0	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	PHD finger protein 21A isoform X1.	0.976
KDM1A	PRDM16	A0A2Y9LLF1	A0A2Y9Q4R0	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	PR domain zinc finger protein 16 isoform X1.	0.916

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