Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ARNT2Aryl hydrocarbon receptor nuclear translocator 2 isoform X1. (717 aa)    
Predicted Functional Partners:
HIF1A
Hypoxia-inducible factor 1-alpha isoform X1.
   
0.993
EPAS1
Endothelial PAS domain-containing protein 1 isoform X1.
   
0.992
NPAS4
Neuronal PAS domain-containing protein 4.
    
 0.955
AHR
Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...]
   
 0.953
ARNT
Aryl hydrocarbon receptor nuclear translocator isoform X1.
  
  
 
0.908
HIF3A
Hypoxia-inducible factor 3-alpha isoform X1.
   
 0.837
NPAS1
Neuronal PAS domain-containing protein 1.
   
 0.815
EGLN1
Egl nine homolog 1.
    
 
 0.789
EGLN3
Egl nine homolog 3.
    
 
 0.789
EGLN2
Egl nine homolog 2.
    
 
 0.789
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.