TOP1MT protein (Delphinapterus leucas) - STRING interaction network

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TOP1MT

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (974 aa)

Predicted Functional Partners:

TOP2B

0.733

TOP2A

0.721

TDP1

0.707

POLE

0.674

RNASEH2A

0.643

WRN

0.639

RECQL4

0.613

BLM

0.602

KLHL35

0.602

KCTD2

0.594

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	KCTD2	A0A2Y9MD57	A0A2Y9PPX3	Bloom syndrome protein isoform X1.	BTB/POZ domain-containing protein KCTD2 isoform X1.	0.592
BLM	POLE	A0A2Y9MD57	A0A2Y9QEF5	Bloom syndrome protein isoform X1.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.661
BLM	RNASEH2A	A0A2Y9MD57	A0A2Y9LZC4	Bloom syndrome protein isoform X1.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.613
BLM	TOP1MT	A0A2Y9MD57	A0A2Y9LMU8	Bloom syndrome protein isoform X1.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.602
BLM	TOP2A	A0A2Y9MD57	A0A2Y9LYD0	Bloom syndrome protein isoform X1.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.541
BLM	TOP2B	A0A2Y9MD57	A0A2Y9LL62	Bloom syndrome protein isoform X1.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.514
BLM	WRN	A0A2Y9MD57	A0A2Y9N622	Bloom syndrome protein isoform X1.	Werner syndrome ATP-dependent helicase isoform X1.	0.709
KCTD2	BLM	A0A2Y9PPX3	A0A2Y9MD57	BTB/POZ domain-containing protein KCTD2 isoform X1.	Bloom syndrome protein isoform X1.	0.592
KCTD2	RECQL4	A0A2Y9PPX3	A0A2Y9LMT5	BTB/POZ domain-containing protein KCTD2 isoform X1.	LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4.	0.592
KCTD2	TOP1MT	A0A2Y9PPX3	A0A2Y9LMU8	BTB/POZ domain-containing protein KCTD2 isoform X1.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.594
KCTD2	TOP2A	A0A2Y9PPX3	A0A2Y9LYD0	BTB/POZ domain-containing protein KCTD2 isoform X1.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.580
KCTD2	TOP2B	A0A2Y9PPX3	A0A2Y9LL62	BTB/POZ domain-containing protein KCTD2 isoform X1.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.580
KCTD2	WRN	A0A2Y9PPX3	A0A2Y9N622	BTB/POZ domain-containing protein KCTD2 isoform X1.	Werner syndrome ATP-dependent helicase isoform X1.	0.688
KLHL35	TOP1MT	A0A2Y9PVM2	A0A2Y9LMU8	Kelch-like protein 35 isoform X1.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.602
POLE	BLM	A0A2Y9QEF5	A0A2Y9MD57	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Bloom syndrome protein isoform X1.	0.661
POLE	RECQL4	A0A2Y9QEF5	A0A2Y9LMT5	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4.	0.692
POLE	RNASEH2A	A0A2Y9QEF5	A0A2Y9LZC4	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.813
POLE	TOP1MT	A0A2Y9QEF5	A0A2Y9LMU8	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.674
POLE	TOP2A	A0A2Y9QEF5	A0A2Y9LYD0	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.505
POLE	TOP2B	A0A2Y9QEF5	A0A2Y9LL62	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.467

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