| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGO1 | AGO2 | A0A2Y9NNP9 | A0A2Y9LPB1 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.936 |
| AGO1 | AGO3 | A0A2Y9NNP9 | A0A2Y9NDB2 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.714 |
| AGO1 | DICER1 | A0A2Y9NNP9 | A0A2Y9NFZ9 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. | 0.953 |
| AGO1 | DROSHA | A0A2Y9NNP9 | A0A2Y9MHJ8 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Ribonuclease 3 isoform X1. | 0.856 |
| AGO1 | IPO8 | A0A2Y9NNP9 | A0A2Y9NHM5 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Importin-8 isoform X1. | 0.553 |
| AGO1 | LOC111175572 | A0A2Y9NNP9 | A0A2Y9N9J5 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.926 |
| AGO1 | TARBP2 | A0A2Y9NNP9 | A0A2Y9MZ17 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.869 |
| AGO1 | TNRC6B | A0A2Y9NNP9 | A0A2Y9QBH6 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Trinucleotide repeat-containing gene 6B protein isoform X1. | 0.524 |
| AGO1 | TSN | A0A2Y9NNP9 | A0A2Y9PM12 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Translin isoform X1. | 0.737 |
| AGO1 | TSNAX | A0A2Y9NNP9 | A0A2Y9LP33 | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | Translin-associated protein X isoform X1. | 0.567 |
| AGO2 | AGO1 | A0A2Y9LPB1 | A0A2Y9NNP9 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Protein argonaute-1 isoform X1; Belongs to the argonaute family. | 0.936 |
| AGO2 | AGO3 | A0A2Y9LPB1 | A0A2Y9NDB2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.940 |
| AGO2 | DICER1 | A0A2Y9LPB1 | A0A2Y9NFZ9 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. | 0.993 |
| AGO2 | DROSHA | A0A2Y9LPB1 | A0A2Y9MHJ8 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Ribonuclease 3 isoform X1. | 0.878 |
| AGO2 | IPO8 | A0A2Y9LPB1 | A0A2Y9NHM5 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Importin-8 isoform X1. | 0.885 |
| AGO2 | LOC111175572 | A0A2Y9LPB1 | A0A2Y9N9J5 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. | 0.900 |
| AGO2 | TARBP2 | A0A2Y9LPB1 | A0A2Y9MZ17 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.944 |
| AGO2 | TNRC6B | A0A2Y9LPB1 | A0A2Y9QBH6 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Trinucleotide repeat-containing gene 6B protein isoform X1. | 0.839 |
| AGO2 | TSN | A0A2Y9LPB1 | A0A2Y9PM12 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Translin isoform X1. | 0.906 |
| AGO2 | TSNAX | A0A2Y9LPB1 | A0A2Y9LP33 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Translin-associated protein X isoform X1. | 0.854 |
STRING v12.5 is now available!
