STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)    
Predicted Functional Partners:
CACYBP
Calcyclin-binding protein.
    
 0.993
CTNNB1
Catenin beta-1.
    
 0.962
AXIN1
Axin-1 isoform X1.
    
 0.861
USP19
Ubiquitin carboxyl-terminal hydrolase 19 isoform X1.
    
 
 0.792
SIAH2
E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
  
 
0.762
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase.
   
 
 0.746
HIPK2
Homeodomain-interacting protein kinase 2 isoform X1.
    
 
 0.732
LOC111167118
Protein S100; Belongs to the S-100 family.
    
 0.708
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 0.708
UBE2V2
Ubiquitin-conjugating enzyme E2 variant 2.
    
   0.657
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.