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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC111166100Complement C3-like isoform X1. (1706 aa)    
Predicted Functional Partners:
CFI
Complement factor I; Belongs to the peptidase S1 family.
   
 0.747
C1S
Complement C1s subcomponent; Belongs to the peptidase S1 family.
   
 0.718
CFB
Complement factor B isoform X1; Belongs to the peptidase S1 family.
   
 0.716
CFH
Complement factor H isoform X1.
   
 0.710
C6
Complement component C6 isoform X1.
   
 0.710
C9
Complement component C9.
   
 0.702
CD55
Complement decay-accelerating factor isoform X1.
   
 0.699
MASP2
Mannan-binding lectin serine protease 2 isoform X1; Belongs to the peptidase S1 family.
   
 0.697
LOC111179563
Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
   
 0.687
C2
Complement C2 isoform X1; Belongs to the peptidase S1 family.
   
 0.683
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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