Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
S1PR5Sphingosine 1-phosphate receptor 5 isoform X1. (510 aa)    
Predicted Functional Partners:
GNAI1
Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1.
    
 0.936
GNAI2
Guanine nucleotide-binding protein G(I) subunit alpha-2.
    
 0.936
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
    
 0.936
GNA12
Guanine nucleotide-binding protein subunit alpha-12 isoform X2.
    
 0.922
GNA13
Guanine nucleotide-binding protein subunit alpha-13.
    
 0.922
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
     
 0.483
LOC111176747
C-type lectin domain family 2 member D11-like isoform X1.
    
 0.466
LOC111176749
Early activation antigen CD69-like.
    
 0.466
GNB4
Guanine nucleotide-binding protein subunit beta-4 isoform X1.
    
  0.401
GNB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2.
    
  0.401
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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