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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPOPSpeckle-type POZ protein. (374 aa)    
Predicted Functional Partners:
CUL3
Cullin-3 isoform X1; Belongs to the cullin family.
   
 0.998
SPOPL
Speckle-type POZ protein-like isoform X1.
  
  
 
0.991
GLI2
Zinc finger protein GLI2.
   
 0.988
GLI1
Zinc finger protein GLI1 isoform X1.
   
 0.980
GLI3
Transcriptional activator GLI3 isoform X1.
   
 0.979
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
     
 0.968
CUL1
Cullin-1; Belongs to the cullin family.
   
 0.855
KCTD2
BTB/POZ domain-containing protein KCTD2 isoform X1.
    
 
 0.787
CACUL1
CDK2-associated and cullin domain-containing protein 1 isoform X1; Belongs to the cullin family.
   
 0.779
RBX1
E3 ubiquitin-protein ligase RBX1.
    
 0.771
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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