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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta-1.
    
 0.992
NLK
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
 0.977
CTBP1
C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.975
JUP
Junction plakoglobin.
    
 0.973
CTBP2
C-terminal-binding protein 2 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.968
EP300
Histone acetyltransferase p300.
   
 0.961
CREBBP
CREB-binding protein isoform X1.
   
 0.960
APC
Adenomatous polyposis coli protein isoform X1.
    
 0.958
SOX17
Transcription factor SOX-17.
    
0.955
RUVBL1
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
    
 0.954
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.