close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LDLRLow-density lipoprotein receptor. (857 aa)    
Predicted Functional Partners:
LDLRAP1
LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1.
    
 0.991
PCSK9
Proprotein convertase subtilisin/kexin type 9 isoform X1.
    
 0.977
APOB
Apolipoprotein B-100.
    
 0.971
MYLIP
E3 ubiquitin-protein ligase MYLIP.
    
 0.962
DAB2
Disabled homolog 2 isoform X1.
    
 0.951
RELN
Reelin isoform X1.
    
 0.798
DAB1
Disabled homolog 1 isoform X1.
    
 0.733
LIPC
Hepatic triacylglycerol lipase isoform X1.
    
 0.692
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.668
ITSN2
Intersectin-2 isoform X1.
    
 0.626
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.