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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIK2Serine/threonine-protein kinase SIK2 isoform X1. (912 aa)    
Predicted Functional Partners:
CRTC2
CREB-regulated transcription coactivator 2 isoform X1.
    
 0.948
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.
   
 
0.907
PRKACB
cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.
   
 
0.907
CRTC3
CREB-regulated transcription coactivator 3 isoform X1.
    
 
 0.699
LOC111183400
CREB-regulated transcription coactivator 3-like.
    
 
 0.699
MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1.
    
 0.628
SCGN
Secretagogin.
     
 0.526
SH3BGRL2
SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family.
      
 0.505
KANK1
KN motif and ankyrin repeat domain-containing protein 1 isoform X3.
    
 0.482
MARK1
Non-specific serine/threonine protein kinase.
  
   
0.460
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.