TPRKB protein (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TPRKB

EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family. (175 aa)

Predicted Functional Partners:

TP53RK

0.991

OSGEP

0.990

OSGEPL1

0.920

NET1

0.615

HTRA3

0.607

GON7

0.514

TCP1

0.507

SLC19A3

0.506

MRPS18C

0.489

OLFM1

0.485

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GON7	OSGEP	A0A2Y9NCR9	A0A2Y9PB98	EKC/KEOPS complex subunit GON7.	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.916
GON7	OSGEPL1	A0A2Y9NCR9	A0A2Y9MVB5	EKC/KEOPS complex subunit GON7.	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	0.708
GON7	TP53RK	A0A2Y9NCR9	A0A2Y9MIC6	EKC/KEOPS complex subunit GON7.	TP53-regulating kinase isoform X1.	0.863
GON7	TPRKB	A0A2Y9NCR9	A0A2Y9MAQ2	EKC/KEOPS complex subunit GON7.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.514
HTRA3	NET1	A0A2Y9LLT8	A0A2Y9MTZ1	Serine protease HTRA3 isoform X1.	Neuroepithelial cell-transforming gene 1 protein isoform X1.	0.514
HTRA3	TCP1	A0A2Y9LLT8	A0A2Y9M2L2	Serine protease HTRA3 isoform X1.	T-complex protein 1 subunit alpha.	0.427
HTRA3	TPRKB	A0A2Y9LLT8	A0A2Y9MAQ2	Serine protease HTRA3 isoform X1.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.607
MRPS18C	TPRKB	A0A2Y9QBS8	A0A2Y9MAQ2	28S ribosomal protein S18c, mitochondrial isoform X1.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.489
NET1	HTRA3	A0A2Y9MTZ1	A0A2Y9LLT8	Neuroepithelial cell-transforming gene 1 protein isoform X1.	Serine protease HTRA3 isoform X1.	0.514
NET1	TPRKB	A0A2Y9MTZ1	A0A2Y9MAQ2	Neuroepithelial cell-transforming gene 1 protein isoform X1.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.615
OLFM1	TPRKB	A0A2Y9NMA3	A0A2Y9MAQ2	Noelin.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.485
OSGEP	GON7	A0A2Y9PB98	A0A2Y9NCR9	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	EKC/KEOPS complex subunit GON7.	0.916
OSGEP	OSGEPL1	A0A2Y9PB98	A0A2Y9MVB5	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	0.479
OSGEP	TP53RK	A0A2Y9PB98	A0A2Y9MIC6	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	TP53-regulating kinase isoform X1.	0.993
OSGEP	TPRKB	A0A2Y9PB98	A0A2Y9MAQ2	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.990
OSGEPL1	GON7	A0A2Y9MVB5	A0A2Y9NCR9	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	EKC/KEOPS complex subunit GON7.	0.708
OSGEPL1	OSGEP	A0A2Y9MVB5	A0A2Y9PB98	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.479
OSGEPL1	TP53RK	A0A2Y9MVB5	A0A2Y9MIC6	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	TP53-regulating kinase isoform X1.	0.935
OSGEPL1	TPRKB	A0A2Y9MVB5	A0A2Y9MAQ2	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.920
SLC19A3	TPRKB	A0A2Y9MX26	A0A2Y9MAQ2	Thiamine transporter 2.	EKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family.	0.506