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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WDR45WD repeat domain phosphoinositide-interacting protein 4 isoform X1. (361 aa)    
Predicted Functional Partners:
TECPR2
Tectonin beta-propeller repeat-containing protein 2 isoform X1.
   
  
 0.773
RB1CC1
RB1-inducible coiled-coil protein 1 isoform X1.
      
 0.723
CUNH16orf70
UPF0183 protein C16orf70 homolog.
   
  
 0.711
SPG11
Spatacsin isoform X1.
      
 0.700
BCAS3
Breast carcinoma-amplified sequence 3 isoform X1.
   
  
 0.654
ATG2B
Autophagy-related protein 2 homolog B isoform X1.
    
 
 0.646
ATG2A
Autophagy-related protein 2 homolog A isoform X1.
    
 
 0.646
PANK2
Pantothenate kinase 2, mitochondrial isoform X1.
      
 0.637
FA2H
Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...]
   
  
 0.636
OTUD5
OTU domain-containing protein 5 isoform X1.
   
  
 0.617
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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