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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1DET1 homolog isoform X1. (573 aa)    
Predicted Functional Partners:
RFWD2
E3 ubiquitin-protein ligase RFWD2 isoform X1.
    
 0.978
DDB2
DNA damage-binding protein 2 isoform X1.
     
 0.934
DDB1
DNA damage-binding protein 1.
    
 
 0.906
ERCC8
DNA excision repair protein ERCC-8 isoform X1.
     
  0.900
CUL4A
cullin-4A; Belongs to the cullin family.
    
 
 0.790
CUL4B
cullin-4B isoform X1; Belongs to the cullin family.
    
 
 0.736
LOC111175787
LOW QUALITY PROTEIN: cullin-4B-like; Belongs to the cullin family.
    
 
 0.736
ATXN7L3
Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]
      
 0.711
DDA1
DET1- and DDB1-associated protein 1.
    
 
 0.661
ETV5
LOW QUALITY PROTEIN: ETS translocation variant 5.
    
 
 0.585
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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