USP21 protein (Delphinapterus leucas) - STRING interaction network

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USP21

Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)

Predicted Functional Partners:

RIPK1

0.982

RPS27A

0.859

ARL16

0.858

GATA3

0.819

IL33

0.777

RNF41

0.743

HGS

0.694

RNF125

0.660

STAM2

0.640

STAM

0.640

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL16	RNF125	A0A2Y9PP14	A0A2Y9P676	ADP-ribosylation factor-like protein 16 isoform X2.	E3 ubiquitin-protein ligase RNF125 isoform X1.	0.759
ARL16	USP21	A0A2Y9PP14	A0A2Y9MC12	ADP-ribosylation factor-like protein 16 isoform X2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.858
GATA3	IL33	A0A2Y9P1J9	A0A2Y9N393	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-33 isoform X1.	0.656
GATA3	USP21	A0A2Y9P1J9	A0A2Y9MC12	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.819
HGS	RPS27A	A0A2Y9PID2	A0A2Y9Q1L7	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	ubiquitin-40S ribosomal protein S27a.	0.908
HGS	STAM	A0A2Y9PID2	A0A2Y9NQR4	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 1.	0.999
HGS	STAM2	A0A2Y9PID2	A0A2Y9MU11	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 2 isoform X1.	0.999
HGS	USP21	A0A2Y9PID2	A0A2Y9MC12	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.694
IL33	GATA3	A0A2Y9N393	A0A2Y9P1J9	Interleukin-33 isoform X1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.656
IL33	USP21	A0A2Y9N393	A0A2Y9MC12	Interleukin-33 isoform X1.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.777
RIPK1	RPS27A	A0A2Y9PAG9	A0A2Y9Q1L7	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	ubiquitin-40S ribosomal protein S27a.	0.590
RIPK1	USP21	A0A2Y9PAG9	A0A2Y9MC12	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.982
RNF125	ARL16	A0A2Y9P676	A0A2Y9PP14	E3 ubiquitin-protein ligase RNF125 isoform X1.	ADP-ribosylation factor-like protein 16 isoform X2.	0.759
RNF125	USP21	A0A2Y9P676	A0A2Y9MC12	E3 ubiquitin-protein ligase RNF125 isoform X1.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.660
RNF41	RPS27A	A0A2Y9N804	A0A2Y9Q1L7	E3 ubiquitin-protein ligase NRDP1 isoform X1.	ubiquitin-40S ribosomal protein S27a.	0.756
RNF41	USP21	A0A2Y9N804	A0A2Y9MC12	E3 ubiquitin-protein ligase NRDP1 isoform X1.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.743
RPS27A	HGS	A0A2Y9Q1L7	A0A2Y9PID2	ubiquitin-40S ribosomal protein S27a.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.908
RPS27A	RIPK1	A0A2Y9Q1L7	A0A2Y9PAG9	ubiquitin-40S ribosomal protein S27a.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.590
RPS27A	RNF41	A0A2Y9Q1L7	A0A2Y9N804	ubiquitin-40S ribosomal protein S27a.	E3 ubiquitin-protein ligase NRDP1 isoform X1.	0.756
RPS27A	STAM	A0A2Y9Q1L7	A0A2Y9NQR4	ubiquitin-40S ribosomal protein S27a.	Signal transducing adapter molecule 1.	0.908

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