Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (947 aa)    
Predicted Functional Partners:
SIRT1
NAD-dependent protein deacetylase sirtuin-1 isoform X1.
    
 0.998
MCC
Colorectal mutant cancer protein isoform X1.
   
  0.930
HAO1
Hydroxyacid oxidase 1 isoform X1.
    
   0.923
RANBP3
Ran-binding protein 3 isoform X1.
   
    0.853
BAG2
BAG family molecular chaperone regulator 2.
    
 
 0.816
PPIL4
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
   
  0.805
MYC
Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
    
 
 0.803
HSPD1
60 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family.
   
   0.802
EDC4
Enhancer of mRNA-decapping protein 4 isoform X1.
   
    0.801
U2AF2
U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.
   
 0.692
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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