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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (947 aa)    
Predicted Functional Partners:
SIRT1
NAD-dependent protein deacetylase sirtuin-1 isoform X1.
    
 0.874
RANBP3
Ran-binding protein 3 isoform X1.
   
    0.803
TMBIM6
Bax inhibitor 1; Belongs to the BI1 family.
      
 0.689
EDC4
Enhancer of mRNA-decapping protein 4 isoform X1.
   
    0.674
PSMB10
Proteasome subunit beta.
    
 
 0.602
RBM39
RNA-binding protein 39 isoform X1.
   
 0.594
HAO1
Hydroxyacid oxidase 1 isoform X1.
    
   0.547
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]
    
 0.538
RNF40
E3 ubiquitin protein ligase; Belongs to the BRE1 family.
   
    0.534
DDX46
Probable ATP-dependent RNA helicase DDX46 isoform X1.
   
 0.533
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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