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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FMR1Synaptic functional regulator FMR1 isoform X1. (632 aa)    
Predicted Functional Partners:
FXR2
Fragile X mental retardation syndrome-related protein 2.
  
 
0.973
CYFIP1
Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.
    
 0.970
FXR1
Fragile X mental retardation syndrome-related protein 1 isoform X1.
  
 
0.968
CYFIP2
Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.
    
 0.965
MECP2
Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
    
 
 0.746
SHANK3
SH3 and multiple ankyrin repeat domains protein 3 isoform X1.
    
 
 0.745
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 
 0.718
SP1
Transcription factor Sp1.
    
 0.715
DIP2B
Disco-interacting protein 2 homolog B isoform X1.
    
 
 0.699
CPEB4
Cytoplasmic polyadenylation element-binding protein 4 isoform X1.
    
 
 0.663
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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