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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIF7Kinesin-like protein KIF7 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1371 aa)    
Predicted Functional Partners:
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.987
GLI3
Transcriptional activator GLI3 isoform X1.
    
 0.983
GLI2
Zinc finger protein GLI2.
    
 0.979
GLI1
Zinc finger protein GLI1 isoform X1.
    
 0.976
STK36
Serine/threonine-protein kinase 36 isoform X1.
   
 0.803
SMO
Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 0.795
CEP41
Centrosomal protein of 41 kDa isoform X1.
      
 0.688
IFT52
Intraflagellar transport protein 52 homolog isoform X1.
     
 0.647
CEP290
Centrosomal protein of 290 kDa.
   
 
 0.640
GPR161
G-protein coupled receptor 161 isoform X1; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.616
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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