STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F12LOW QUALITY PROTEIN: coagulation factor XII. (650 aa)    
Predicted Functional Partners:
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
  
0.961
SERPINC1
antithrombin-III isoform X1; Belongs to the serpin family.
   
 0.957
LOC111173428
Coagulation factor XI; Belongs to the peptidase S1 family.
  
0.952
LOC111178618
Collagen alpha-1(I) chain-like.
   
 0.930
PTK7
Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.832
KNG1
Kininogen-1 isoform X1.
   
 0.830
MET
Hepatocyte growth factor receptor isoform X1.
    
 0.814
MST1R
Macrophage-stimulating protein receptor isoform X1.
    
 0.802
RNASEL
2-5A-dependent ribonuclease isoform X1.
   
 0.724
RIPK4
Receptor-interacting serine/threonine-protein kinase 4 isoform X1.
   
 0.721
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.