HR protein (Delphinapterus leucas) - STRING interaction network

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[Homology]

Score

HR

Lysine-specific demethylase hairless isoform X1. (1177 aa)

Predicted Functional Partners:

RAD51

0.542

POLR2F

0.519

RAD52

0.517

LVRN

0.515

FOXI3

0.514

WASHC1

0.514

NSUN5

0.514

BRCA2

0.508

BRCA1

0.506

POLR2C

0.497

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	BRCA2	A0A2Y9LXF5	A0A2Y9NLY0	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Breast cancer type 2 susceptibility protein.	0.999
BRCA1	HR	A0A2Y9LXF5	A0A2Y9MHQ6	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Lysine-specific demethylase hairless isoform X1.	0.506
BRCA1	RAD51	A0A2Y9LXF5	A0A2Y9P7Z2	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.982
BRCA1	RAD52	A0A2Y9LXF5	A0A2Y9NFX6	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA repair protein RAD52 homolog isoform X1.	0.831
BRCA2	BRCA1	A0A2Y9NLY0	A0A2Y9LXF5	Breast cancer type 2 susceptibility protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BRCA2	HR	A0A2Y9NLY0	A0A2Y9MHQ6	Breast cancer type 2 susceptibility protein.	Lysine-specific demethylase hairless isoform X1.	0.508
BRCA2	RAD51	A0A2Y9NLY0	A0A2Y9P7Z2	Breast cancer type 2 susceptibility protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.999
BRCA2	RAD52	A0A2Y9NLY0	A0A2Y9NFX6	Breast cancer type 2 susceptibility protein.	DNA repair protein RAD52 homolog isoform X1.	0.689
FOXI3	HR	A0A2Y9LXQ9	A0A2Y9MHQ6	Forkhead box protein I3.	Lysine-specific demethylase hairless isoform X1.	0.514
HR	BRCA1	A0A2Y9MHQ6	A0A2Y9LXF5	Lysine-specific demethylase hairless isoform X1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.506
HR	BRCA2	A0A2Y9MHQ6	A0A2Y9NLY0	Lysine-specific demethylase hairless isoform X1.	Breast cancer type 2 susceptibility protein.	0.508
HR	FOXI3	A0A2Y9MHQ6	A0A2Y9LXQ9	Lysine-specific demethylase hairless isoform X1.	Forkhead box protein I3.	0.514
HR	LVRN	A0A2Y9MHQ6	A0A2Y9PHP0	Lysine-specific demethylase hairless isoform X1.	Aminopeptidase.	0.515
HR	NSUN5	A0A2Y9MHQ6	A0A2Y9PEQ1	Lysine-specific demethylase hairless isoform X1.	Probable 28S rRNA (Cytosine-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.514
HR	POLR2C	A0A2Y9MHQ6	A0A2Y9LQK1	Lysine-specific demethylase hairless isoform X1.	DNA-directed RNA polymerase II subunit RPB3.	0.497
HR	POLR2F	A0A2Y9MHQ6	A0A2Y9Q5D0	Lysine-specific demethylase hairless isoform X1.	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1.	0.519
HR	RAD51	A0A2Y9MHQ6	A0A2Y9P7Z2	Lysine-specific demethylase hairless isoform X1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.542
HR	RAD52	A0A2Y9MHQ6	A0A2Y9NFX6	Lysine-specific demethylase hairless isoform X1.	DNA repair protein RAD52 homolog isoform X1.	0.517
HR	WASHC1	A0A2Y9MHQ6	A0A2Y9NU53	Lysine-specific demethylase hairless isoform X1.	WASH complex subunit 1 isoform X1.	0.514
LVRN	HR	A0A2Y9PHP0	A0A2Y9MHQ6	Aminopeptidase.	Lysine-specific demethylase hairless isoform X1.	0.515