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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)    
Predicted Functional Partners:
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.962
MAP3K4
Mitogen-activated protein kinase kinase kinase 4 isoform X1.
    
 0.961
CCNB1
G2/mitotic-specific cyclin-B1; Belongs to the cyclin family.
    
 0.943
CDK1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
 0.937
CCNB2
G2/mitotic-specific cyclin-B2 isoform X1; Belongs to the cyclin family.
    
 0.922
GADD45A
Growth arrest and DNA damage-inducible protein GADD45 alpha.
  
0.922
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
     
 0.922
GADD45G
Growth arrest and DNA damage-inducible protein GADD45 gamma.
  
 
0.919
CCNB3
LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3; Belongs to the cyclin family.
    
 0.915
CSRNP1
Cysteine/serine-rich nuclear protein 1.
   
  
 0.731
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.