STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase 2-binding protein 1 isoform X1. (1520 aa)    
Predicted Functional Partners:
BARD1
BRCA1-associated RING domain protein 1.
   
 0.987
CDC45
Cell division control protein 45 homolog isoform X1.
   
 
 0.985
RAD9B
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.978
TP53BP1
TP53-binding protein 1 isoform X1.
    
 
 0.978
ATRIP
ATR-interacting protein isoform X1.
    
 0.972
BRIP1
Fanconi anemia group J protein isoform X1.
   
 0.970
ATR
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.965
MCM5
DNA helicase; Belongs to the MCM family.
   
 
 0.962
RTEL1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]
   
 0.955
MCM3
DNA helicase; Belongs to the MCM family.
   
 
 0.954
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.