STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)    
Predicted Functional Partners:
FGFR1
Fibroblast growth factor receptor.
    
 0.985
FGFR2
Fibroblast growth factor receptor.
    
 0.973
FGFR3
Fibroblast growth factor receptor.
    
 0.919
FGFR4
Fibroblast growth factor receptor 4.
    
 0.874
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
 0.861
FGF18
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
     
 0.836
FLT3
Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.824
PDGFRB
Platelet-derived growth factor receptor beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.816
TEK
Angiopoietin-1 receptor isoform X1.
    
 0.811
KDR
Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.807
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.