STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HGFACHepatocyte growth factor activator isoform X1. (663 aa)    
Predicted Functional Partners:
WDR90
WD repeat-containing protein 90.
   
 0.901
HGF
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
   
0.900
SPINT1
Kunitz-type protease inhibitor 1 isoform X1.
    
 0.859
MET
Hepatocyte growth factor receptor.
    
 0.849
PTK7
Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.841
MST1R
Macrophage-stimulating protein receptor.
    
 0.808
LOC102983302
Trypsin-like isoform X1; Belongs to the peptidase S1 family.
  
 
0.800
ENSPCTP00005001651
annotation not available
  
 
0.797
C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial.
    
 0.756
RNASEL
2-5A-dependent ribonuclease isoform X1.
   
 0.735
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.