STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)    
Predicted Functional Partners:
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
 
 0.999
IL1R2
Interleukin 1 receptor type 2.
   
 0.976
IL1R1
Interleukin 1 receptor type 1.
   
 0.972
CAPN1
Calpain 1; Belongs to the peptidase C2 family.
   
 
 0.903
CAPN2
Calpain 2; Belongs to the peptidase C2 family.
   
 
 0.903
S100A13
S100 calcium binding protein A13; Belongs to the S-100 family.
    
 
 0.884
IL1RAP
Interleukin 1 receptor accessory protein.
   
 0.848
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 
 0.826
LOC100666284
Interleukin-1.
   
  
 0.806
CSF2
Colony stimulating factor 2.
   
 
 0.803
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.