HLX protein (Loxodonta africana) - STRING interaction network

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[Homology]

Score

HLX

H2.0 like homeobox. (491 aa)

Predicted Functional Partners:

TLE1

0.787

NUP160

0.599

ARHGEF2

0.496

ESRRB

0.493

ESRRG

0.493

RAB20

0.440

DRGX

0.426

IMPDH1

0.423

IMPDH2

0.423

AKIRIN2

0.409

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKIRIN2	ARHGEF2	ENSLAFP00000011642	ENSLAFP00000009383	Akirin 2.	Rho/Rac guanine nucleotide exchange factor 2.	0.518
AKIRIN2	HLX	ENSLAFP00000011642	ENSLAFP00000001086	Akirin 2.	H2.0 like homeobox.	0.409
AKIRIN2	IMPDH1	ENSLAFP00000011642	ENSLAFP00000006789	Akirin 2.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.493
AKIRIN2	IMPDH2	ENSLAFP00000011642	ENSLAFP00000010726	Akirin 2.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.493
ARHGEF2	AKIRIN2	ENSLAFP00000009383	ENSLAFP00000011642	Rho/Rac guanine nucleotide exchange factor 2.	Akirin 2.	0.518
ARHGEF2	HLX	ENSLAFP00000009383	ENSLAFP00000001086	Rho/Rac guanine nucleotide exchange factor 2.	H2.0 like homeobox.	0.496
ARHGEF2	IMPDH1	ENSLAFP00000009383	ENSLAFP00000006789	Rho/Rac guanine nucleotide exchange factor 2.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.467
ARHGEF2	IMPDH2	ENSLAFP00000009383	ENSLAFP00000010726	Rho/Rac guanine nucleotide exchange factor 2.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.467
DRGX	HLX	ENSLAFP00000017780	ENSLAFP00000001086	Dorsal root ganglia homeobox.	H2.0 like homeobox.	0.426
ESRRB	HLX	ENSLAFP00000013031	ENSLAFP00000001086	Estrogen related receptor beta.	H2.0 like homeobox.	0.493
ESRRG	HLX	ENSLAFP00000017867	ENSLAFP00000001086	Estrogen related receptor gamma.	H2.0 like homeobox.	0.493
HLX	AKIRIN2	ENSLAFP00000001086	ENSLAFP00000011642	H2.0 like homeobox.	Akirin 2.	0.409
HLX	ARHGEF2	ENSLAFP00000001086	ENSLAFP00000009383	H2.0 like homeobox.	Rho/Rac guanine nucleotide exchange factor 2.	0.496
HLX	DRGX	ENSLAFP00000001086	ENSLAFP00000017780	H2.0 like homeobox.	Dorsal root ganglia homeobox.	0.426
HLX	ESRRB	ENSLAFP00000001086	ENSLAFP00000013031	H2.0 like homeobox.	Estrogen related receptor beta.	0.493
HLX	ESRRG	ENSLAFP00000001086	ENSLAFP00000017867	H2.0 like homeobox.	Estrogen related receptor gamma.	0.493
HLX	IMPDH1	ENSLAFP00000001086	ENSLAFP00000006789	H2.0 like homeobox.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.423
HLX	IMPDH2	ENSLAFP00000001086	ENSLAFP00000010726	H2.0 like homeobox.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.423
HLX	NUP160	ENSLAFP00000001086	ENSLAFP00000012785	H2.0 like homeobox.	Nucleoporin 160.	0.599
HLX	RAB20	ENSLAFP00000001086	ENSLAFP00000007566	H2.0 like homeobox.	RAB20, member RAS oncogene family.	0.440

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