STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TBKBP1TBK1 binding protein 1. (547 aa)    
Predicted Functional Partners:
TBK1
TANK binding kinase 1.
   
 
 0.971
TANK
TRAF family member associated NFKB activator.
     
 0.900
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 
 0.863
AZI2
Uncharacterized protein.
   
 0.862
CALCOCO2
Calcium binding and coiled-coil domain 2.
    
 
 0.846
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
     
 0.832
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
   0.506
KPNB1
Karyopherin subunit beta 1.
 
    
 0.496
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 
 0.452
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 
 0.452
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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