MYC protein (Loxodonta africana) - STRING interaction network

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MYC

Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)

Predicted Functional Partners:

MAX

0.995

ZBTB17

0.991

CDKN2B

0.984

USP28

0.975

CTNNB1

0.969

FBXW7

0.968

BRCA1

0.966

EP300

0.963

SKP2

0.955

GSK3B

0.953

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	CDKN2B	ENSLAFP00000012177	ENSLAFP00000016776	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cyclin dependent kinase inhibitor 2B.	0.478
BRCA1	EP300	ENSLAFP00000012177	ENSLAFP00000010281	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E1A binding protein p300.	0.943
BRCA1	MYC	ENSLAFP00000012177	ENSLAFP00000001181	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.966
BRCA1	SKP2	ENSLAFP00000012177	ENSLAFP00000004500	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	S-phase kinase associated protein 2.	0.646
CDKN2B	BRCA1	ENSLAFP00000016776	ENSLAFP00000012177	Cyclin dependent kinase inhibitor 2B.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.478
CDKN2B	CTNNB1	ENSLAFP00000016776	ENSLAFP00000015325	Cyclin dependent kinase inhibitor 2B.	Catenin beta 1.	0.491
CDKN2B	MYC	ENSLAFP00000016776	ENSLAFP00000001181	Cyclin dependent kinase inhibitor 2B.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.984
CTNNB1	CDKN2B	ENSLAFP00000015325	ENSLAFP00000016776	Catenin beta 1.	Cyclin dependent kinase inhibitor 2B.	0.491
CTNNB1	EP300	ENSLAFP00000015325	ENSLAFP00000010281	Catenin beta 1.	E1A binding protein p300.	0.992
CTNNB1	FBXW7	ENSLAFP00000015325	ENSLAFP00000014201	Catenin beta 1.	F-box and WD repeat domain containing 7.	0.851
CTNNB1	GSK3B	ENSLAFP00000015325	ENSLAFP00000006574	Catenin beta 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.980
CTNNB1	MAX	ENSLAFP00000015325	ENSLAFP00000015453	Catenin beta 1.	MYC associated factor X.	0.462
CTNNB1	MYC	ENSLAFP00000015325	ENSLAFP00000001181	Catenin beta 1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.969
EP300	BRCA1	ENSLAFP00000010281	ENSLAFP00000012177	E1A binding protein p300.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.943
EP300	CTNNB1	ENSLAFP00000010281	ENSLAFP00000015325	E1A binding protein p300.	Catenin beta 1.	0.992
EP300	MAX	ENSLAFP00000010281	ENSLAFP00000015453	E1A binding protein p300.	MYC associated factor X.	0.804
EP300	MYC	ENSLAFP00000010281	ENSLAFP00000001181	E1A binding protein p300.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.963
EP300	SKP2	ENSLAFP00000010281	ENSLAFP00000004500	E1A binding protein p300.	S-phase kinase associated protein 2.	0.828
EP300	ZBTB17	ENSLAFP00000010281	ENSLAFP00000003778	E1A binding protein p300.	Zinc finger and BTB domain containing 17.	0.602
FBXW7	CTNNB1	ENSLAFP00000014201	ENSLAFP00000015325	F-box and WD repeat domain containing 7.	Catenin beta 1.	0.851

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