STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PJA2Praja ring finger ubiquitin ligase 2. (709 aa)    
Predicted Functional Partners:
MOB1A
MOB kinase activator 1A.
    
 
 0.801
FAF2
Fas associated factor family member 2.
   
 
 0.670
DNAJC16
DnaJ heat shock protein family (Hsp40) member C16.
   
 
 0.605
UBXN1
UBX domain protein 1.
   
 
 0.593
CREBRF
CREB3 regulatory factor.
   
 0.589
PSMD11
Proteasome 26S subunit, non-ATPase 11.
    
 
 0.565
FAF1
Fas associated factor 1.
   
 
 0.555
UBXN7
UBX domain-containing protein 7.
   
 
 0.550
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 
 0.548
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.536
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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