STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)    
Predicted Functional Partners:
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.997
CDKN1A
Cyclin dependent kinase inhibitor 1A.
   
 0.994
CDK3
Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.
   
 0.987
CDKN1B
Cyclin dependent kinase inhibitor 1B.
   
 0.981
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.974
SKP2
S-phase kinase associated protein 2.
   
 0.972
RB1
RB transcriptional corepressor 1.
   
 0.970
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.965
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.963
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.958
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.