STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (947 aa)    
Predicted Functional Partners:
GART
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
  
 0.994
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.
  
 0.961
SHMT2
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.942
GLDC
Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.941
SHMT1
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.911
MTHFR
Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 0.901
MTHFD2
Uncharacterized protein.
  
0.900
AMT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
  
 0.893
FPGS
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
  
 
 0.890
MTHFD2L
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.
  
 0.887
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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