STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRAK4Interleukin 1 receptor associated kinase 4. (459 aa)    
Predicted Functional Partners:
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.997
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.997
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.988
TIRAP
TIR domain containing adaptor protein.
   
 0.987
IRAK2
Interleukin 1 receptor associated kinase 2.
    
 0.986
PELI1
E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
    
 0.981
TLR4
Toll like receptor 4; Belongs to the Toll-like receptor family.
   
 0.979
IRAK3
Interleukin 1 receptor associated kinase 3.
    
 0.958
TOLLIP
Toll interacting protein.
    
 0.941
TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1.
   
 0.939
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.