Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.995
GRB2
Growth factor receptor bound protein 2.
    
 0.962
CBLB
Cbl proto-oncogene B.
    
 0.939
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.939
ZDHHC17
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
    
   0.759
SPRY1
Sprouty RTK signaling antagonist 1.
   
  0.744
EGFR
Receptor protein-tyrosine kinase.
    
 0.647
HBEGF
Heparin binding EGF like growth factor.
   
 
 0.637
SH3KBP1
SH3 domain containing kinase binding protein 1.
    
 0.633
EREG
Epiregulin.
     
 0.618
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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