Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
PDE10APhosphodiesterase. (490 aa)    
Predicted Functional Partners:
GUCY2C
Guanylate cyclase.
   
 0.966
AMPD3
AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
     
 0.920
ADK
Adenosine kinase.
     
 0.911
NT5E
5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.
     
 0.907
AK2
Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
     
 0.906
AK8
Adenylate kinase 8; Belongs to the adenylate kinase family.
     
 0.906
CANT1
Calcium activated nucleotidase 1.
     
 0.904
AK9
Uncharacterized protein.
     
 0.902
ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase 3.
    
 0.901
AK3
Adenylate kinase 3; Belongs to the adenylate kinase family.
     
 0.899
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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