STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)    
Predicted Functional Partners:
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
   
 0.999
XPA
XPA, DNA damage recognition and repair factor.
    
 0.997
SLX4
SLX4 structure-specific endonuclease subunit.
   
 0.990
FANCM
FA complementation group M.
   
 0.983
MUS81
MUS81 structure-specific endonuclease subunit.
   
 0.977
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
     
 0.963
GIYD1
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
   
 0.940
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
   
 
 0.933
RAD23B
RAD23 homolog B, nucleotide excision repair protein.
    
 0.931
XPC
XPC complex subunit, DNA damage recognition and repair factor.
     
 0.904
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.